Effects of multidomain lifestyle intervention, omega-3 supplementation or their combination on physical activity levels in older adults: secondary analysis of the Multidomain Alzheimer Preventive Trial (MAPT) randomised controlled trial.
Identifieur interne : 000962 ( Main/Exploration ); précédent : 000961; suivant : 000963Effects of multidomain lifestyle intervention, omega-3 supplementation or their combination on physical activity levels in older adults: secondary analysis of the Multidomain Alzheimer Preventive Trial (MAPT) randomised controlled trial.
Auteurs : Philipe De Souto Barreto [France] ; Yves Rolland [France] ; Matteo Cesari [France] ; Charlotte Dupuy [France] ; Sandrine Andrieu [France] ; Bruno Vellas [France]Source :
- Age and ageing [ 1468-2834 ] ; 2018.
Descripteurs français
- KwdFr :
- Acides gras omega-3 (administration et posologie), Appréciation des risques (MeSH), Cognition (MeSH), Compléments alimentaires (MeSH), Comportement de réduction des risques (MeSH), Exercice physique (MeSH), Facteurs de protection (MeSH), Facteurs de risque (MeSH), Facteurs temps (MeSH), Facteurs âges (MeSH), Femelle (MeSH), France (MeSH), Humains (MeSH), Maladie d'Alzheimer (diagnostic), Maladie d'Alzheimer (prévention et contrôle), Maladie d'Alzheimer (psychologie), Mode de vie sain (MeSH), Mâle (MeSH), Mémoire (MeSH), Résultat thérapeutique (MeSH), Sujet âgé (MeSH), Sujet âgé de 80 ans ou plus (MeSH), Thérapie cognitive (MeSH), Troubles de la mémoire (diagnostic), Troubles de la mémoire (psychologie), Troubles de la mémoire (thérapie), Vieillissement en bonne santé (psychologie).
- MESH :
- administration et posologie : Acides gras omega-3.
- diagnostic : Maladie d'Alzheimer, Troubles de la mémoire.
- prévention et contrôle : Maladie d'Alzheimer.
- psychologie : Maladie d'Alzheimer, Troubles de la mémoire, Vieillissement en bonne santé.
- thérapie : Troubles de la mémoire.
- Appréciation des risques, Cognition, Compléments alimentaires, Comportement de réduction des risques, Exercice physique, Facteurs de protection, Facteurs de risque, Facteurs temps, Facteurs âges, Femelle, France, Humains, Mode de vie sain, Mâle, Mémoire, Résultat thérapeutique, Sujet âgé, Sujet âgé de 80 ans ou plus, Thérapie cognitive.
- Wicri :
- geographic : France.
English descriptors
- KwdEn :
- Age Factors (MeSH), Aged (MeSH), Aged, 80 and over (MeSH), Alzheimer Disease (diagnosis), Alzheimer Disease (prevention & control), Alzheimer Disease (psychology), Cognition (MeSH), Cognitive Behavioral Therapy (MeSH), Dietary Supplements (MeSH), Exercise (MeSH), Fatty Acids, Omega-3 (administration & dosage), Female (MeSH), France (MeSH), Healthy Aging (psychology), Healthy Lifestyle (MeSH), Humans (MeSH), Male (MeSH), Memory (MeSH), Memory Disorders (diagnosis), Memory Disorders (psychology), Memory Disorders (therapy), Protective Factors (MeSH), Risk Assessment (MeSH), Risk Factors (MeSH), Risk Reduction Behavior (MeSH), Time Factors (MeSH), Treatment Outcome (MeSH).
- MESH :
- chemical , administration & dosage : Fatty Acids, Omega-3.
- geographic : France.
- diagnosis : Alzheimer Disease, Memory Disorders.
- prevention & control : Alzheimer Disease.
- psychology : Alzheimer Disease, Healthy Aging, Memory Disorders.
- therapy : Memory Disorders.
- Age Factors, Aged, Aged, 80 and over, Cognition, Cognitive Behavioral Therapy, Dietary Supplements, Exercise, Female, Healthy Lifestyle, Humans, Male, Memory, Protective Factors, Risk Assessment, Risk Factors, Risk Reduction Behavior, Time Factors, Treatment Outcome.
Abstract
Background/objectives
to investigate the effects of a 3-year multidomain lifestyle intervention, omega-3 supplementation or both on physical activity (PA) in older adults with subjective memory complaints.
Design/settings/subjects
the Multidomain Alzheimer Preventive Trial was a 3-year randomised controlled trial that enroled 1,680 community-dwelling adults aged 70 years or over, with subjective memory complaints. Participants were randomised to omega-3 supplementation (total daily dose of 800 mg docosahexanoic acid and up to 225 mg eicosapentanoic acid), multidomain intervention (nutritional and exercise counselling and cognitive training), omega-3 plus multidomain intervention or placebo with usual care.
Methods
PA was assessed using a self-reported questionnaire. From this, global moderate-to-vigorous PA, leisure-time PA, non-leisure-time PA and light PA were measured in metabolic equivalent tasks-minutes per week (MET-min/week).
Results
in the multidomain groups, participants significantly increased their moderate-to-vigorous and leisure-time PA at 6 months (≥300 MET-min/week for both in the multidomain groups; P ≤ 0.002) before returning to baseline by the end of the trial. Activity in the placebo/usual care and omega-3/usual care groups declined overtime. Between-group differences remained significant for both multidomain groups for leisure-time physical activity at 2- and 3-year follow-ups. Compared to placebo/usual care, interventions had no significant effects on non-leisure-time PA and light PA. Omega-3 supplementation alone had no effects on PA.
Conclusions
a multidomain intervention focused on cognitive training, and nutritional and PA counselling increased PA in the short-term and limited its decline in the long-term among older adults with memory complaints. ClinicalTrials.gov-Registration number: NCT0067268.
DOI: 10.1093/ageing/afx164
PubMed: 29136094
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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wicri:level="3"><nlm:affiliation>Gérontopôle de Toulouse, Institut du Vieillissement, Centre Hospitalo-Universitaire de Toulouse (CHU Toulouse), Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Gérontopôle de Toulouse, Institut du Vieillissement, Centre Hospitalo-Universitaire de Toulouse (CHU Toulouse), Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>UMR INSERM 1027, University of Toulouse III, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>UMR INSERM 1027, University of Toulouse III, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement 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sort="Barreto, Philipe De Souto" uniqKey="Barreto P" first="Philipe De Souto" last="Barreto">Philipe De Souto Barreto</name><affiliation wicri:level="3"><nlm:affiliation>Gérontopôle de Toulouse, Institut du Vieillissement, Centre Hospitalo-Universitaire de Toulouse (CHU Toulouse), Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Gérontopôle de Toulouse, Institut du Vieillissement, Centre Hospitalo-Universitaire de Toulouse (CHU Toulouse), Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>UMR INSERM 1027, University of Toulouse III, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>UMR INSERM 1027, University of Toulouse III, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Rolland, Yves" sort="Rolland, Yves" uniqKey="Rolland Y" first="Yves" last="Rolland">Yves Rolland</name><affiliation wicri:level="3"><nlm:affiliation>Gérontopôle de Toulouse, Institut du Vieillissement, Centre Hospitalo-Universitaire de Toulouse (CHU Toulouse), Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Gérontopôle de Toulouse, Institut du Vieillissement, Centre Hospitalo-Universitaire de Toulouse (CHU Toulouse), Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>UMR INSERM 1027, University of Toulouse III, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>UMR INSERM 1027, University of Toulouse III, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Cesari, Matteo" sort="Cesari, Matteo" uniqKey="Cesari M" first="Matteo" last="Cesari">Matteo Cesari</name><affiliation wicri:level="3"><nlm:affiliation>Gérontopôle de Toulouse, Institut du Vieillissement, Centre Hospitalo-Universitaire de Toulouse (CHU Toulouse), Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Gérontopôle de Toulouse, Institut du Vieillissement, Centre Hospitalo-Universitaire de Toulouse (CHU Toulouse), Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>UMR INSERM 1027, University of Toulouse III, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>UMR INSERM 1027, University of Toulouse III, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Dupuy, Charlotte" sort="Dupuy, Charlotte" uniqKey="Dupuy C" first="Charlotte" last="Dupuy">Charlotte Dupuy</name><affiliation wicri:level="3"><nlm:affiliation>Gérontopôle de Toulouse, Institut du Vieillissement, Centre Hospitalo-Universitaire de Toulouse (CHU Toulouse), Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Gérontopôle de Toulouse, Institut du Vieillissement, Centre Hospitalo-Universitaire de Toulouse (CHU Toulouse), Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Andrieu, Sandrine" sort="Andrieu, Sandrine" uniqKey="Andrieu S" first="Sandrine" last="Andrieu">Sandrine Andrieu</name><affiliation wicri:level="3"><nlm:affiliation>Gérontopôle de Toulouse, Institut du Vieillissement, Centre Hospitalo-Universitaire de Toulouse (CHU Toulouse), Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Gérontopôle de Toulouse, Institut du Vieillissement, Centre Hospitalo-Universitaire de Toulouse (CHU Toulouse), Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>UMR INSERM 1027, University of Toulouse III, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>UMR INSERM 1027, University of Toulouse III, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Vellas, Bruno" sort="Vellas, Bruno" uniqKey="Vellas B" first="Bruno" last="Vellas">Bruno Vellas</name><affiliation wicri:level="3"><nlm:affiliation>Gérontopôle de Toulouse, Institut du Vieillissement, Centre Hospitalo-Universitaire de Toulouse (CHU Toulouse), Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Gérontopôle de Toulouse, Institut du Vieillissement, Centre Hospitalo-Universitaire de Toulouse (CHU Toulouse), Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>UMR INSERM 1027, University of Toulouse III, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>UMR INSERM 1027, University of Toulouse III, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author></analytic><series><title level="j">Age and ageing</title><idno type="eISSN">1468-2834</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age Factors (MeSH)</term><term>Aged (MeSH)</term><term>Aged, 80 and over (MeSH)</term><term>Alzheimer Disease (diagnosis)</term><term>Alzheimer Disease (prevention & control)</term><term>Alzheimer Disease (psychology)</term><term>Cognition (MeSH)</term><term>Cognitive Behavioral Therapy (MeSH)</term><term>Dietary Supplements (MeSH)</term><term>Exercise (MeSH)</term><term>Fatty Acids, Omega-3 (administration & dosage)</term><term>Female (MeSH)</term><term>France (MeSH)</term><term>Healthy Aging (psychology)</term><term>Healthy Lifestyle (MeSH)</term><term>Humans (MeSH)</term><term>Male (MeSH)</term><term>Memory (MeSH)</term><term>Memory Disorders (diagnosis)</term><term>Memory Disorders (psychology)</term><term>Memory Disorders (therapy)</term><term>Protective Factors (MeSH)</term><term>Risk Assessment (MeSH)</term><term>Risk Factors (MeSH)</term><term>Risk Reduction Behavior (MeSH)</term><term>Time Factors (MeSH)</term><term>Treatment Outcome (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acides gras omega-3 (administration et posologie)</term><term>Appréciation des risques (MeSH)</term><term>Cognition (MeSH)</term><term>Compléments alimentaires (MeSH)</term><term>Comportement de réduction des risques (MeSH)</term><term>Exercice physique (MeSH)</term><term>Facteurs de protection (MeSH)</term><term>Facteurs de risque (MeSH)</term><term>Facteurs temps (MeSH)</term><term>Facteurs âges (MeSH)</term><term>Femelle (MeSH)</term><term>France (MeSH)</term><term>Humains (MeSH)</term><term>Maladie d'Alzheimer (diagnostic)</term><term>Maladie d'Alzheimer (prévention et contrôle)</term><term>Maladie d'Alzheimer (psychologie)</term><term>Mode de vie sain (MeSH)</term><term>Mâle (MeSH)</term><term>Mémoire (MeSH)</term><term>Résultat thérapeutique (MeSH)</term><term>Sujet âgé (MeSH)</term><term>Sujet âgé de 80 ans ou plus (MeSH)</term><term>Thérapie cognitive (MeSH)</term><term>Troubles de la mémoire (diagnostic)</term><term>Troubles de la mémoire (psychologie)</term><term>Troubles de la mémoire (thérapie)</term><term>Vieillissement en bonne santé (psychologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Fatty Acids, Omega-3</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>France</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Acides gras omega-3</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Alzheimer Disease</term><term>Memory Disorders</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Maladie d'Alzheimer</term><term>Troubles de la mémoire</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Alzheimer Disease</term></keywords><keywords scheme="MESH" qualifier="prévention et contrôle" xml:lang="fr"><term>Maladie d'Alzheimer</term></keywords><keywords scheme="MESH" qualifier="psychologie" xml:lang="fr"><term>Maladie d'Alzheimer</term><term>Troubles de la mémoire</term><term>Vieillissement en bonne santé</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Alzheimer Disease</term><term>Healthy Aging</term><term>Memory Disorders</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Memory Disorders</term></keywords><keywords scheme="MESH" qualifier="thérapie" xml:lang="fr"><term>Troubles de la mémoire</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Age Factors</term><term>Aged</term><term>Aged, 80 and over</term><term>Cognition</term><term>Cognitive Behavioral Therapy</term><term>Dietary Supplements</term><term>Exercise</term><term>Female</term><term>Healthy Lifestyle</term><term>Humans</term><term>Male</term><term>Memory</term><term>Protective Factors</term><term>Risk Assessment</term><term>Risk Factors</term><term>Risk Reduction Behavior</term><term>Time Factors</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Appréciation des risques</term><term>Cognition</term><term>Compléments alimentaires</term><term>Comportement de réduction des risques</term><term>Exercice physique</term><term>Facteurs de protection</term><term>Facteurs de risque</term><term>Facteurs temps</term><term>Facteurs âges</term><term>Femelle</term><term>France</term><term>Humains</term><term>Mode de vie sain</term><term>Mâle</term><term>Mémoire</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Thérapie cognitive</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>France</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>Background/objectives</b></p><p>to investigate the effects of a 3-year multidomain lifestyle intervention, omega-3 supplementation or both on physical activity (PA) in older adults with subjective memory complaints.</p></div><div type="abstract" xml:lang="en"><p><b>Design/settings/subjects</b></p><p>the Multidomain Alzheimer Preventive Trial was a 3-year randomised controlled trial that enroled 1,680 community-dwelling adults aged 70 years or over, with subjective memory complaints. Participants were randomised to omega-3 supplementation (total daily dose of 800 mg docosahexanoic acid and up to 225 mg eicosapentanoic acid), multidomain intervention (nutritional and exercise counselling and cognitive training), omega-3 plus multidomain intervention or placebo with usual care.</p></div><div type="abstract" xml:lang="en"><p><b>Methods</b></p><p>PA was assessed using a self-reported questionnaire. From this, global moderate-to-vigorous PA, leisure-time PA, non-leisure-time PA and light PA were measured in metabolic equivalent tasks-minutes per week (MET-min/week).</p></div><div type="abstract" xml:lang="en"><p><b>Results</b></p><p>in the multidomain groups, participants significantly increased their moderate-to-vigorous and leisure-time PA at 6 months (≥300 MET-min/week for both in the multidomain groups; P ≤ 0.002) before returning to baseline by the end of the trial. Activity in the placebo/usual care and omega-3/usual care groups declined overtime. Between-group differences remained significant for both multidomain groups for leisure-time physical activity at 2- and 3-year follow-ups. Compared to placebo/usual care, interventions had no significant effects on non-leisure-time PA and light PA. Omega-3 supplementation alone had no effects on PA.</p></div><div type="abstract" xml:lang="en"><p><b>Conclusions</b></p><p>a multidomain intervention focused on cognitive training, and nutritional and PA counselling increased PA in the short-term and limited its decline in the long-term among older adults with memory complaints. ClinicalTrials.gov-Registration number: NCT0067268.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29136094</PMID><DateCompleted><Year>2019</Year><Month>09</Month><Day>23</Day></DateCompleted><DateRevised><Year>2019</Year><Month>09</Month><Day>23</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1468-2834</ISSN><JournalIssue CitedMedium="Internet"><Volume>47</Volume><Issue>2</Issue><PubDate><Year>2018</Year><Month>Mar</Month><Day>01</Day></PubDate></JournalIssue><Title>Age and ageing</Title><ISOAbbreviation>Age Ageing</ISOAbbreviation></Journal><ArticleTitle>Effects of multidomain lifestyle intervention, omega-3 supplementation or their combination on physical activity levels in older adults: secondary analysis of the Multidomain Alzheimer Preventive Trial (MAPT) randomised controlled trial.</ArticleTitle><Pagination><MedlinePgn>281-288</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1093/ageing/afx164</ELocationID><Abstract><AbstractText Label="Background/objectives">to investigate the effects of a 3-year multidomain lifestyle intervention, omega-3 supplementation or both on physical activity (PA) in older adults with subjective memory complaints.</AbstractText><AbstractText Label="Design/settings/subjects">the Multidomain Alzheimer Preventive Trial was a 3-year randomised controlled trial that enroled 1,680 community-dwelling adults aged 70 years or over, with subjective memory complaints. Participants were randomised to omega-3 supplementation (total daily dose of 800 mg docosahexanoic acid and up to 225 mg eicosapentanoic acid), multidomain intervention (nutritional and exercise counselling and cognitive training), omega-3 plus multidomain intervention or placebo with usual care.</AbstractText><AbstractText Label="Methods">PA was assessed using a self-reported questionnaire. From this, global moderate-to-vigorous PA, leisure-time PA, non-leisure-time PA and light PA were measured in metabolic equivalent tasks-minutes per week (MET-min/week).</AbstractText><AbstractText Label="Results">in the multidomain groups, participants significantly increased their moderate-to-vigorous and leisure-time PA at 6 months (≥300 MET-min/week for both in the multidomain groups; P ≤ 0.002) before returning to baseline by the end of the trial. Activity in the placebo/usual care and omega-3/usual care groups declined overtime. Between-group differences remained significant for both multidomain groups for leisure-time physical activity at 2- and 3-year follow-ups. Compared to placebo/usual care, interventions had no significant effects on non-leisure-time PA and light PA. Omega-3 supplementation alone had no effects on PA.</AbstractText><AbstractText Label="Conclusions">a multidomain intervention focused on cognitive training, and nutritional and PA counselling increased PA in the short-term and limited its decline in the long-term among older adults with memory complaints. ClinicalTrials.gov-Registration number: NCT0067268.</AbstractText><CopyrightInformation>© The Author 2017. Published by Oxford University Press on behalf of the British Geriatrics Society.All rights reserved. For permissions, please email: journals.permissions@oup.com</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Barreto</LastName><ForeName>Philipe de Souto</ForeName><Initials>PS</Initials><AffiliationInfo><Affiliation>Gérontopôle de Toulouse, Institut du Vieillissement, Centre Hospitalo-Universitaire de Toulouse (CHU Toulouse), Toulouse, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>UMR INSERM 1027, University of Toulouse III, Toulouse, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rolland</LastName><ForeName>Yves</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Gérontopôle de Toulouse, Institut du Vieillissement, Centre Hospitalo-Universitaire de Toulouse (CHU Toulouse), Toulouse, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>UMR INSERM 1027, University of Toulouse III, Toulouse, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cesari</LastName><ForeName>Matteo</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Gérontopôle de Toulouse, Institut du Vieillissement, Centre Hospitalo-Universitaire de Toulouse (CHU Toulouse), Toulouse, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>UMR INSERM 1027, University of Toulouse III, Toulouse, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dupuy</LastName><ForeName>Charlotte</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Gérontopôle de Toulouse, Institut du Vieillissement, Centre Hospitalo-Universitaire de Toulouse (CHU Toulouse), Toulouse, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Andrieu</LastName><ForeName>Sandrine</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Gérontopôle de Toulouse, Institut du Vieillissement, Centre Hospitalo-Universitaire de Toulouse (CHU Toulouse), Toulouse, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>UMR INSERM 1027, University of Toulouse III, Toulouse, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vellas</LastName><ForeName>Bruno</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Gérontopôle de Toulouse, Institut du Vieillissement, Centre Hospitalo-Universitaire de Toulouse (CHU Toulouse), Toulouse, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>UMR INSERM 1027, University of Toulouse III, Toulouse, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>MAPT study group</CollectiveName></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Age Ageing</MedlineTA><NlmUniqueID>0375655</NlmUniqueID><ISSNLinking>0002-0729</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015525">Fatty Acids, Omega-3</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000367" MajorTopicYN="N">Age Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000544" MajorTopicYN="N">Alzheimer Disease</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName><QualifierName UI="Q000523" MajorTopicYN="N">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003071" MajorTopicYN="N">Cognition</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015928" MajorTopicYN="Y">Cognitive Behavioral Therapy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019587" MajorTopicYN="Y">Dietary Supplements</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015444" MajorTopicYN="Y">Exercise</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015525" MajorTopicYN="N">Fatty Acids, Omega-3</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005602" MajorTopicYN="N" Type="Geographic">France</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000073656" MajorTopicYN="Y">Healthy Aging</DescriptorName><QualifierName UI="Q000523" MajorTopicYN="N">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000070497" MajorTopicYN="Y">Healthy Lifestyle</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008568" MajorTopicYN="Y">Memory</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008569" MajorTopicYN="N">Memory Disorders</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000523" MajorTopicYN="N">psychology</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D065840" MajorTopicYN="N">Protective Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018570" MajorTopicYN="N">Risk Assessment</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D040242" MajorTopicYN="Y">Risk Reduction Behavior</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year><Month>04</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>10</Month><Day>03</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>11</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>9</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>11</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">29136094</ArticleId><ArticleId IdType="pii">4616535</ArticleId><ArticleId IdType="doi">10.1093/ageing/afx164</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li></country><region><li>Midi-Pyrénées</li><li>Occitanie (région administrative)</li></region><settlement><li>Toulouse</li></settlement></list><tree><country name="France"><region name="Occitanie (région administrative)"><name sortKey="Barreto, Philipe De Souto" sort="Barreto, Philipe De Souto" uniqKey="Barreto P" first="Philipe De Souto" last="Barreto">Philipe De Souto Barreto</name></region><name sortKey="Andrieu, Sandrine" sort="Andrieu, Sandrine" uniqKey="Andrieu S" first="Sandrine" last="Andrieu">Sandrine Andrieu</name><name sortKey="Andrieu, Sandrine" sort="Andrieu, Sandrine" uniqKey="Andrieu S" first="Sandrine" last="Andrieu">Sandrine Andrieu</name><name sortKey="Barreto, Philipe De Souto" sort="Barreto, Philipe De Souto" uniqKey="Barreto P" first="Philipe De Souto" last="Barreto">Philipe De Souto Barreto</name><name sortKey="Cesari, Matteo" sort="Cesari, Matteo" uniqKey="Cesari M" first="Matteo" last="Cesari">Matteo Cesari</name><name sortKey="Cesari, Matteo" sort="Cesari, Matteo" uniqKey="Cesari M" first="Matteo" last="Cesari">Matteo Cesari</name><name sortKey="Dupuy, Charlotte" sort="Dupuy, Charlotte" uniqKey="Dupuy C" first="Charlotte" last="Dupuy">Charlotte Dupuy</name><name sortKey="Rolland, Yves" sort="Rolland, Yves" uniqKey="Rolland Y" first="Yves" last="Rolland">Yves Rolland</name><name sortKey="Rolland, Yves" sort="Rolland, Yves" uniqKey="Rolland Y" first="Yves" last="Rolland">Yves Rolland</name><name sortKey="Vellas, Bruno" sort="Vellas, Bruno" uniqKey="Vellas B" first="Bruno" last="Vellas">Bruno Vellas</name><name sortKey="Vellas, Bruno" 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